Auditorium
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17:00 |
Opening |
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17:30 |
PLENARY LECTURE AI-based digital twins for accelerating time to market and optimizing biomanufacturing |
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18:30 |
Reception (Foyer) |
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18:50 |
PLENARY LECTURE History of ESBES & Industrial Biotech in Delft |
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19:10 |
Reception (Foyer) |
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20:00 |
Reception end |
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13:30 |
PLENARY LECTURE Methods and Technologies for Bioprocess Development in Microbial and Cell Culture Systems |
Session 1a - DIG1
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14:30 |
A holistic and modular framework for modeling packed bed liquid chromatography |
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14:50 |
Accurate AI augmented information retrieval from research article for RefoldDB |
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15:10 |
Analysis across scales: integrated insights in metabolism and economic feasibility of recombinant protein production from carbon dioxide and hydrogen |
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15:30 |
Beyond the Ideal Mixing assumption: Dynamic Simulation of Industrial Bioreactor Heterogeneity |
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16:00 |
Poster session 1 (Foyer) |
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17:00 |
Drinks |
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09:00 |
workshop 1 |
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10:30 |
Coffee break |
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11:00 |
workshop 1 |
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12:30 |
Lunch break |
Session 1b - BME1
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14:30 |
Automation Across Scales: High-Throughput Strain Engineering and Bioprocess Validation of Indigoidine Production in Corynebacterium glutamicum |
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14:50 |
Autonomous dynamic control of overflow metabolism |
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15:10 |
Engineering a fully genomically re-coded strain for single-molecule tracking and biomanufacturing |
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15:30 |
Engineering cyanobacteria for light-driven oxgygenase biocatalysis on gram scale |
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16:00 |
Poster session 1 (Foyer) |
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17:00 |
Drinks |
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09:00 |
workshop 2 |
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10:30 |
Coffee break |
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11:00 |
workshop 2 |
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12:30 |
Lunch break |
Session 1c - BCAT1
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14:30 |
3D-Printed Agarose TPMS Monoliths as Continuous-Flow Immobilized Enzyme Reactors for Starch Hydrolysis |
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14:50 |
Alkane Hydroxylation by Anchored Unspecific Peroxygenase |
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15:10 |
Cascade bio-catalysis for efficient synthesis of nucleosides and nucleotides |
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15:30 |
Developing hybrid living materials utilizing Pseudomonas biofilms for continuous adipic acid production from cyclohexanol |
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16:00 |
Poster session 1 (Foyer) |
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17:00 |
Drinks |
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09:00 |
workshop 3 |
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10:30 |
Coffee break |
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11:00 |
workshop 3 |
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12:30 |
Lunch break |
Session 1d - USP1
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14:30 |
Bacterial cellulose–chitosan hybrid hydrogels as sustainable 3D matrix for stem-cell culture |
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14:50 |
Controlled Growth Arrest by Sulfate Limitation Enhances Plasmid DNA Production in Vibrio natriegens |
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15:10 |
ENGINEERING 3D CELL CULTURE PLATFORMS USING AQUEOUS TWO-PHASE SYSTEMS FOR UPSTREAM BIOPROCESSING APPLICATIONS |
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15:30 |
Intensified fermentation enables a new dawn for large-scale fermentation |
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16:00 |
Poster session 1 (Foyer) |
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17:00 |
Drinks |
Session 2a - DIG2
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09:00 |
CFD-Informed Machine Learning for Real-Time Prediction of 3D Substrate Gradients in Stirred-Tank Bioreactors |
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09:20 |
Coupling Genome-scale Models with Compartment Bioreactor Models to Study Intracellular Responses under Fluctutating Conditions |
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09:40 |
Digital Twin aided Process Development towards Autonomous Manufacturing of TIDES |
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10:00 |
FerroFlow: unlocking simulation software for Bioprocesses – control strategy optimization for industrial penicillin production |
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10:30 |
Coffee break |
Session 3a - DIG3
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11:00 |
From CFD to Fast Surrogates: Dynamic Compartment Models for Bioreactors |
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11:20 |
From Data to Decision: Hybrid Modeling as a Strategic Accelerator for Platform-Based Nanobody® Development |
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11:40 |
From Lab to Scale: Multi-Fidelity Bayesian Optimisation for Efficient Bioprocess Development |
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12:00 |
Hybrid deep modelling of monoclonal antibody glycosylation by CHO cells |
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12:30 |
Lunch break |
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13:30 |
PLENARY LECTURE A systems engineering approach to accelerating sustainable, bioprocess development |
Session 4a - DIG4
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14:30 |
LEVERAGING BIOPROCESSING 4.0 TOOLS TO FACILITATE AND ACCELERATE THE SCALE-UP OF MICROBIAL FERMENTATION PROCESSES |
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14:50 |
Physics-informed ensemble modelling of PHA production by Cupriavidus necator |
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15:10 |
Software architecture for digital twin development in microalgae photobioreactor facilities |
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15:30 |
Toward Foundation Models for Industrial Mixing Hydrodynamics |
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16:00 |
Poster session 2 (Foyer) |
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17:00 |
Drinks |
Dinner
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19:00 |
Dinner (New Church) |
Session 2b - BME2
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09:00 |
Expanding the product range in Synechocystis: stable production of malate in fluctuating environments |
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09:20 |
Implementation of an O2 tolerant hydrogenase in Synechocystis |
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09:40 |
Integration of metabolic flux analysis and process models for mesenchymal stromal cell cultivation |
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10:00 |
Scalable Pseudomonas Phenol Bioproduction by Stress Response Engineering |
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10:30 |
Coffee break |
Session 3b - DSP1
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11:00 |
A Standardised Microfluidic TFF Platform for Scale Relevant, Low Volume UF/DF Process Development |
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11:20 |
Advancing Virus-like Particle Downstream Processing with Size-Selective Processing & PAT Tools |
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11:40 |
High-Throughput Screening of Precipitation-Driven Partitioning of AAV Virus-Like Particles in PEG/Phosphate Systems Using UV-Derived Scattering |
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12:00 |
Impact of crystal properties on vacuum filtration of L-tyrosine towards an integrated bioprocess |
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12:30 |
Lunch break |
Session 4b - DSP2
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14:30 |
Integrated Magnetic Nanoparticle-Based Capture for Intensified Recombinant Protein Production in Escherichia coli |
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14:50 |
Model-Based Design of Experiments for Spray Drying Using Frozen Airflow CFD-DPM Simulations |
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15:10 |
Optimizing polyhydroxyalkanoates recovery from mixed microbial cultures using supercritical carbon dioxide coupled with solvent extraction: A Taguchi methodology approach |
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15:30 |
Revisiting Expanded Bed Adsorption: Direct Protein Capture from Crude Broths Using Low-Cost Silica |
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16:00 |
Poster session 2 (Foyer) |
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17:00 |
Drinks |
Dinner
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19:00 |
Dinner (New Church) |
Session 2c - BCAT2
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09:00 |
Enzymatic treatment of the lipid effluent in a continuous stirred catalytic basket reactor |
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09:20 |
Evaluating porous materials for cultivating recombinant Synechocystis PCC6803 biofilms to produce poly-caprolactone monomers from cyclohexanol |
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09:40 |
Photosynthesis-driven whole-cell biocatalysis using rec. Synechocystis sp. PCC 6803 for the production of polymer-building blocks |
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10:00 |
Whole-cell Multi-step Biocatalysis for the Renewable Production of 6-Amino hexanoic acid |
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10:30 |
Coffee break |
Session 3c - SUSD1
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11:00 |
A Dynamic 1D Gas–Liquid Modeling Framework for Heterogeneous Bioreactors across Multiple Cultivation Modes |
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11:20 |
A Hybrid Oxygen Capture Model Integrated with CFD for Efficient Scale-Up of a Fixed-Bed Bioreactor |
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11:40 |
A Low-Cost Programmable Platform for Fermentation Scale-Up Research |
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12:00 |
A Scalable V-Shaped Photobiofilm Reactor for Limnospira platensis Biomass Production |
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12:30 |
Lunch break |
Session 4c - SUSD2
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14:30 |
From oxygen transfer to transcriptional robustness: identifying the kLa modulon of Corynebacterium glutamicum |
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14:50 |
High-throughput process development using modelling approaches for soluble expression in E. coli |
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15:10 |
Model-Based Prediction of Scale-Up Behavior in Engineered E. coli for Enzyme Production: A Coupled Kinetic–CFD Strategy |
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15:30 |
Translating experience of gas-permeable membranes from the wastewater sector to the industrial biotechnology sector |
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16:00 |
Poster session 2 (Foyer) |
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17:00 |
Drinks |
Dinner
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19:00 |
Dinner (New Church) |
Session 2d - USP2
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09:00 |
Multifactorial Analysis of HEK293-F Cell Aggregation: Uncovering the Role and Interactions of Bioprocess and Medium Factors. |
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09:20 |
Overcoming Oxygen Transfer Limitations in High-Viscosity Aerobic Fermentation via Sparger-Integrated Internals and Engineered Bimodal Bubble Dynamics |
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09:40 |
Particle-assisted cultivation of filamentous fungi in shaken bioreactors for controlling morphology |
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10:00 |
Shedding light on metabolic burden in (industrial) bioprocesses: Quantifying cellular stress across expression levels in Escherichia coli |
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10:30 |
Coffe break |
Session 3d - USP3
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11:00 |
The Fundamentals of Bioprocessing for Integration of Tyrosine Production |
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11:20 |
Thirteen in One: Production and Purification of a Multi-Epitope Vaccine Candidate Against Schistosomiasis |
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11:40 |
Toward sustainable production of bacteriocins from lactic acid bacteria: medium optimization, fed-batch fermentation and membrane-based recovery |
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12:00 |
Towards a platform process for recombinant protein production in Vibrio natriegens |
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12:30 |
Lunch break |
Session 4d - USP4
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14:50 |
Upstream Process Development for Continuous pDNA manufacturing: A combined experimental and modelling approach |
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14:30 |
Upstream Bioprocessing Strategies for the Co-production of Omega-3 Fatty Acids and Fucoxanthin by Phaeodactylum tricornutum |
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15:10 |
Vibrio natriegens as a novel host for RNA therapeutics |
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15:30 |
pH control and ethanol-to-acetate ratio as key levers for n-caproate selectivity in pure Clostridium kluyveri batch cultures |
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16:00 |
Poster session 2 (Foyer) |
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17:00 |
Drinks |
Dinner
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19:00 |
Dinner (New Church) |
Session 5a - CIRCB1
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09:00 |
Anaerobic co-fermentation of waste sludge and fruit waste: harnessing feeding dynamics for enhanced productivity and tailoring of polyhydroxyalkanoate (PHA) precursors |
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09:20 |
Circular Valorization of Cotton Textile waste for Poly(3-hydroxybutyrate) Production by Burkholderia thailandensis |
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09:40 |
Closing the Loop: Microalgae-Derived EPS for Wastewater Treatment and Bioproduct Recovery from Malting Effluent |
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10:00 |
Continuous and Mild Processing Strategies for Protein Recovery from Food Side Streams within a Circular Bioeconomy |
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10:30 |
Coffee break |
Session 6a - CIRCB2
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11:00 |
Converting waste gases into value: novel avenues for gas fermentation processes |
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11:20 |
Engineered and natural phosphorus recovery through carbonaceous materials produced from contrasting lignocellulosic residues: tequila bagasse–vinasse and Eichhornia crassipes |
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11:40 |
Ex-ante comparison of carbon sources for large-scale aerobic fermentation |
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12:00 |
Integrated biorefinery approach for lactic acid production and extraction: from biomass to monomer |
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12:30 |
Lunch break |
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13:30 |
PLENARY LECTURE TBD |
Session 7a - CIRCB3
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14:30 |
Production of Medium-Chain-Length Polyhydroxyalkanoates from Black Soldier Fly Larvae Oil by Pseudomonas chlororaphis subsp. aurantiaca |
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14:50 |
Sustainable Production of PHBHV with Tunable 3HV Content by Burkholderia thailandensis using Eucalyptus Bark Hydrolysate and Levulinic Acid |
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15:10 |
Sustainable production of the plant probiotic K. pseudosacchari TL13 and of its exopolysaccharide with potential biotechnological applications |
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15:30 |
Techno-Economic and Life Cycle Assessment of Industrial-Scale High-Pressure Extraction of High-Value Bioactives from Forest-Derived Biomass Side Streams |
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16:00 |
CLOSING |
Session 5c - PAT1
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09:00 |
Applications of Raman Spectroscopy and Mid-Infrared Analytics for Characterization of T-Cell Phenotype and Metabolic State |
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09:20 |
Automated PAT Model Development Using Genetic Algorithm-Based Pipeline Optimization |
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09:40 |
Balancing Prediction Performance and Spectral Interpretability: Multi-Metric Guided Design of Preprocessing Pipelines for Rapid Calibration of Raman Spectroscopy Models. |
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10:00 |
Multimodal spectroscopy-based real-time monitoring and anomaly detection in ADC manufacturing process |
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10:30 |
Coffee break |
Session 6c - PAT2
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11:00 |
Predictive control and real-time optimization is a necessity for robust and high performing bioprocesses: experimental emphasis from P. chrysogenum, CHO, C. glutamicum and E. coli |
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11:20 |
Scalable, continuous production of mRNA with real-time prediction of titer and purity via a Digital Twin |
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11:40 |
Subpopulation-based bioprocess design and control |
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12:00 |
Establishment and Digital Monitoring of Quillaja saponaria Plant Cell Suspension Cultures for QS-21 Production |
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12:30 |
Lunch break |
Session 7c - EDU
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14:30 |
Avatar-based Conversational AI Assistant in Chemical Engineering Education |
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14:50 |
Closing the Gap: Challenge-Based, Industry co-created laboratory for undergraduate bioprocess development |
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15:10 |
Helix Lab - Center for Applied Research and Education in an Industrial Environment |
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15:30 |
More than just modelling and programming: educating engineers to leverage their digital skills in practice. |
Session 5d - BPHARM1
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09:00 |
A phenomenological modeling approach to designing freezing processes for human induced pluripotent stem cell-derived spheroids |
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09:20 |
Cell-Tolerant Radial Affinity Chromatography for Capture of Monoclonal Antibodies from Unclarified Harvest |
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09:40 |
CFD-DEM characterization of a 250 mL stirred-tank bioreactor for shear-sensitive stem-cell microcarrier cultures |
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10:00 |
Engineering Simplified and Scalable Manufacturing Platforms for Circular RNA Therapeutics |
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10:30 |
Coffee break |
Session 6d - BFHARM2
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11:00 |
PEGYLATION OF SILK FIBROIN NANOPARTICLES FOR DELIVERY OF 3,3’-DIINDOLYLMETHANE IN A ROUTE FOR OBESITY MANAGEMENT |
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11:20 |
PROCESS DEVELOPMENT FOR SCALABLE PRODUCTION OF IPSC-DERIVED HEMATOPOIETIC STEM/PROGENITOR CELLS IN STIRRED-TANK BIOREACTORS |
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11:40 |
Deep hybrid modelling of CHO platforms: addressing multiple development campaigns across different antibody products |
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12:30 |
Lunch break |
Session 5b - DSP3
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09:00 |
Rotating Dynamic Crossflow Microfiltration as an Active Harvesting Platform for Continuous High-Cell-Density Escherichia coli Biomanufacturing |
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09:20 |
Steric exclusion chromatography for scalable purification of ssDNA scaffolds in DNA-origami biomanufacturing |
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09:40 |
Digital Twin aided Process Development and Enablement of Autonomous Manufacturing of Synthetic Peptides |
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10:00 |
A Mechanistic Model for Predicting AAV9 Recovery During Ion-Exchange Purification |
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10:30 |
Coffee break |
Session 6b - BF&CA1
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11:00 |
Dairy Side-Stream Valorization Through Microbial Lipid Production: Comparative Assessment of Yarrowia lipolytica and Candida kefyr |
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11:20 |
Real-time monitoring of stress responses of lactic acid bacteria for industrial applications |
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11:40 |
Yarrowia-driven solid-state fermentation of Portuguese fruit surpluses |
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12:00 |
Life cycle assessment of integral production chains for cellular agriculture products |
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12:30 |
Lunch break |
Session 7b - BF&CA2
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14:30 |
A Platform Approach to Cultivated Meat: scalable cells, high-throughput screening, and computational modeling |
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14:50 |
Cultured seafood: a tissue engineering approach |
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15:10 |
How large can you go? Model-based screening of bioreactors for large scale cultivated meat production. |
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15:30 |
Integrating upstream cultivations and downstream processes: The impact of cultivation conditions on intracellular protein release from mildly disrupted Saccharomyces cerevisiae |