Scientific Programme


Auditorium

17:00

Opening
Conference chair opening address

17:30

PLENARY LECTURE AI-based digital twins for accelerating time to market and optimizing biomanufacturing
Christoph Herwig, Lisalis GmbH, Austria

18:30

Reception (Foyer)

18:50

PLENARY LECTURE History of ESBES & Industrial Biotech in Delft
Karel Luyben

19:10

Reception (Foyer)

20:00

Reception end

13:30

PLENARY LECTURE Methods and Technologies for Bioprocess Development in Microbial and Cell Culture Systems
Jørgen Magnus


Session 1a - DIG1

14:30

A holistic and modular framework for modeling packed bed liquid chromatography
Jan Breuer1, Gregor Gassner2, Samuel Leweke1, Johannes Schmölder1, Eric von Lieres1
1 Forschungszentrum Jülich, Jülich, Germany
2 Universität Köln, Cologne, Germany

14:50

Accurate AI augmented information retrieval from research article for RefoldDB
Xavier Delfosse1, Simon Duerr1, Matthias Rüdt1
1 HES-SO, Valais-Wallis, Sion, Switzerland

15:10

Analysis across scales: integrated insights in metabolism and economic feasibility of recombinant protein production from carbon dioxide and hydrogen
Tobias Alter1, Lars Blank1, Titania Sugiarto1, Samira Van Den Bogaard1
1 RWTH Aachen University - institute of Applied Microbiology, Aachen, Germany

15:30

Beyond the Ideal Mixing assumption: Dynamic Simulation of Industrial Bioreactor Heterogeneity
Krist Gernaey 1, Ulrich Krühne1, Johan Le Nepvou De Carfort1, Víctor Puig I Laborda1
1 Technical University of Denmark, Kongens Lyngby, Denmark

16:00

Poster session 1 (Foyer)

17:00

Drinks

09:00

workshop 1

10:30

Coffee break

11:00

workshop 1

12:30

Lunch break


Session 1b - BME1

14:30

Automation Across Scales: High-Throughput Strain Engineering and Bioprocess Validation of Indigoidine Production in Corynebacterium glutamicum
Max Denter1, Stephan Noack1, Tobias Michael Rosch1
1 Forschungszentrum Jülich GmbH, Jülich, Germany

14:50

Autonomous dynamic control of overflow metabolism
Alvaro R Lara1
1 Aarhus University, Aarhus, Denmark

15:10

Engineering a fully genomically re-coded strain for single-molecule tracking and biomanufacturing
Filip Ilievski1
1 Yale University, New Haven, United States of America

15:30

Engineering cyanobacteria for light-driven oxgygenase biocatalysis on gram scale
Bruno Bühler1, Jörg Toepel1, Adrian Tüllinghoff1
1 Helmholtz Centre for Environmental Research GmbH - UFZ, Leipzig, Germany

16:00

Poster session 1 (Foyer)

17:00

Drinks

09:00

workshop 2

10:30

Coffee break

11:00

workshop 2

12:30

Lunch break


Session 1c - BCAT1

14:30

3D-Printed Agarose TPMS Monoliths as Continuous-Flow Immobilized Enzyme Reactors for Starch Hydrolysis
Sean Feast 1, Conan Fee2, Ali Nazmi2, Pavithra Perera2
1 Precision Chroma LTD, Christchurch, New Zealand
2 School of Product Design, University of Canterbury, Christchurch, New Zealand

14:50

Alkane Hydroxylation by Anchored Unspecific Peroxygenase
Iker Aguirrezabal Telleria1, Stephen Bennett2, Didier Lecouturier3, Myint Toe4
1 University of Basque Country, Bilbao, Spain
2 Johnson Matthey Plc, Reading, United Kingdom
3 University of Lille, Lille, France
4 University of Lille / University of Basque Country / Johnson Matthey Plc, Reading, United Kingdom

15:10

Cascade bio-catalysis for efficient synthesis of nucleosides and nucleotides
Oliver Damm1, Pfeiffer Martin1, Bernd Nidetzky1, Andrej Ribar1
1 Graz University of Technology, Graz, Austria

15:30

Developing hybrid living materials utilizing Pseudomonas biofilms for continuous adipic acid production from cyclohexanol
Katja Bühler1, Micjel Chávez Morejón1, Alexander Franz2, Alper Gürarslan3, Falk Harnisch1, Rohan Karande2, Tilo Pompe2, Aathira Prakash2, Canan Usta3
1 Helmholtz Centre for Environmental Research GmbH - UFZ, Leipzig, Germany
2 Leipzig University, Leipzig, Germany
3 Istanbul Technical University, Istanbul, Turkey

16:00

Poster session 1 (Foyer)

17:00

Drinks

09:00

workshop 3

10:30

Coffee break

11:00

workshop 3

12:30

Lunch break


Session 1d - USP1

14:30

Bacterial cellulose–chitosan hybrid hydrogels as sustainable 3D matrix for stem-cell culture
Angeles Blanco1, Ainhoa Cia1, Diego Lopez-Monte1, M. Concepcion Monte1, Carlos Negro1
1 Universidad Complutense de Madrid, Madrid, Spain

14:50

Controlled Growth Arrest by Sulfate Limitation Enhances Plasmid DNA Production in Vibrio natriegens
Nicolas Cruz Bournazou1, Mathias Gotsmy2, Gonzalo Guillén-Gosálbez 2, Rosa Hassfurther1, Annina Kemmer 1, Peter Neubauer1
1 Chair of Bioprocess Engineering, TU Berlin, Berlin, Germany
2 Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland

15:10

ENGINEERING 3D CELL CULTURE PLATFORMS USING AQUEOUS TWO-PHASE SYSTEMS FOR UPSTREAM BIOPROCESSING APPLICATIONS
Mirna González-González1, Marco Rito-Palomares1
1 Tecnologico de Monterrey, Monterrey, Mexico

15:30

Intensified fermentation enables a new dawn for large-scale fermentation
Eric van der Meer1
1 DAB.bio, Delft, Netherlands

16:00

Poster session 1 (Foyer)

17:00

Drinks


Session 2a - DIG2

09:00

CFD-Informed Machine Learning for Real-Time Prediction of 3D Substrate Gradients in Stirred-Tank Bioreactors
Jorge Carrasco Muriel1, Andrea Castañeda Tena1, Krist V. Gernaey2, Teddy Groves1, Cees Haringa3, Lars Keld Nielsen4, Ulrich Krühne2, Johan le Nepvou de Cafort2, Ignasi Puig de Dou5, Víctor Puig I Laborda6
1 DTU-Biosustain (Bright), Denmark
2 PROSYS-KT (DTU), Denmark
3 TU Delft, Netherlands
4 UQ / DTU-Biosustian (Bright) , Australia
5 UPC, Spain
6 PROSYS-KT, DTU, København, Denmark

09:20

Coupling Genome-scale Models with Compartment Bioreactor Models to Study Intracellular Responses under Fluctutating Conditions
Titania Insani Sugiarto1
1 Industrial System Biotechnology (ISBt) Aachen, Aachen, Germany

09:40

Digital Twin aided Process Development towards Autonomous Manufacturing of TIDES
Marcel Broocks1, Jessica Lütge1, Atzin Moran Mendoza1, Axel Schmidt1, Tom O. J. Schulz1, Jochen Strube1, Alexander Uhl1
1 Institute for Separation and Process Technology, Clausthal University of Technology, Clausthal-Zellerfeld, Germany

10:00

FerroFlow: unlocking simulation software for Bioprocesses – control strategy optimization for industrial penicillin production
Merlin Alvarado Morales1, Pierre Guilloteau1, Gürkan Sin1
1 Technical University of Denmark, Kgs, Lyngby, Denmark

10:30

Coffee break


Session 3a - DIG3

11:00

From CFD to Fast Surrogates: Dynamic Compartment Models for Bioreactors
Cees Haringa1, Hector Maldonado de Leon1, Adrie Straathof1
1 Delft University of Technology, Delft, Netherlands

11:20

From Data to Decision: Hybrid Modeling as a Strategic Accelerator for Platform-Based Nanobody® Development
Maurice Finger1
1 Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany

11:40

From Lab to Scale: Multi-Fidelity Bayesian Optimisation for Efficient Bioprocess Development
Alessandro Butté1, Antonio del Rio Chanona2, Laura Marie Helleckes2, Adrian Martens2, Mathias Neufang2, Moritz von Stosch1
1 DataHow AG, Zürich, Switzerland
2 Imperial College London, London, United Kingdom

12:00

Hybrid deep modelling of monoclonal antibody glycosylation by CHO cells
Leonor Gündersen1, Rui Oliveira1, José Pinto1
1 Systems Biology & Engineering group, Chemistry Department, School of Sciences and Technology, NOVA School of Science and Technology, Associação para a Inovação e Desenvolvimento da FCT NOVA, Campus de Caparica, 2829- 516 Lisbon, Portugal, Caparica, Portugal

12:30

Lunch break

13:30

PLENARY LECTURE A systems engineering approach to accelerating sustainable, bioprocess development
Maria Papathanasiou


Session 4a - DIG4

14:30

LEVERAGING BIOPROCESSING 4.0 TOOLS TO FACILITATE AND ACCELERATE THE SCALE-UP OF MICROBIAL FERMENTATION PROCESSES
Xavier Garcia Ortega1
1 Universitat Autònoma de Barcelona, Bellaterra, Spain

14:50

Physics-informed ensemble modelling of PHA production by Cupriavidus necator
Rafael S. Costa1, Filomena Freitas1, Rui Oliveira1, José Pinto1, Maria A.M. Reis1, Bruno Serafim1, Monesh Kumar Thirugnanasambandam1
1 NOVA School of Science and Technology, Universidade NOVA de Lisboa, Lisbon, Portugal

15:10

Software architecture for digital twin development in microalgae photobioreactor facilities
Maria Barbosa1, Luca Buscaglia1, Marcel Janssen1
1 Bioprocess Engineering, Wageningen University, Wageningen, Netherlands

15:30

Toward Foundation Models for Industrial Mixing Hydrodynamics
Mahdi Naderibeni1, David M.J. Tax1, Liang Wu2
1 TU Delft, Delft, Netherlands
2 dsm-firmenich, Delft, Netherlands

16:00

Poster session 2 (Foyer)

17:00

Drinks


Dinner

19:00

Dinner (New Church)


Session 2b - BME2

09:00

Expanding the product range in Synechocystis: stable production of malate in fluctuating environments
Filipe Branco dos Santos1, Wei Du1, Loles Hoogerland1
1 University of Amsterdam, Amsterdam, Netherlands

09:20

Implementation of an O2 tolerant hydrogenase in Synechocystis
Jörg Toepel1
1 Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany

09:40

Integration of metabolic flux analysis and process models for mesenchymal stromal cell cultivation
Yusuke Hayashi1, Daiki Ikuta1, Hiroki Kikukawa1, Masaki Nishikawa1, Gaku Shimodaira1, Hirokazu Sugiyama1
1 The University of Tokyo, Tokyo, Japan

10:00

Scalable Pseudomonas Phenol Bioproduction by Stress Response Engineering
Constantin Maaß1, Jørgen Magnus1, Till Redeker2, Valentin Steier1, Nick Wierckx2
1 RWTH Aachen University, Aachen, Germany
2 Forschungszentrum Jülich, Jülich, Germany

10:30

Coffee break


Session 3b - DSP1

11:00

A Standardised Microfluidic TFF Platform for Scale Relevant, Low Volume UF/DF Process Development
Nusrat Jahan1, Spyridon Konstantinidis2, Marco Marques3, Nicolas Szita1
1 UCL, London, United Kingdom
2 Merck & Co., Inc., West Point, United States of America
3 UCL, West Point, United Kingdom

11:20

Advancing Virus-like Particle Downstream Processing with Size-Selective Processing & PAT Tools
Annabelle Dietrich1, Juergen Hubbuch1
1 Karlsruhe Institute of Technology (KIT)

11:40

High-Throughput Screening of Precipitation-Driven Partitioning of AAV Virus-Like Particles in PEG/Phosphate Systems Using UV-Derived Scattering
Jürgen Hubbuch1, Giulia Polazzo1, Maria Victoria Schutzmeier1, Malte Schwarzer1
1 Karlsruhe Institute of Technology, Karlsruhe, Germany

12:00

Impact of crystal properties on vacuum filtration of L-tyrosine towards an integrated bioprocess
Julian Kager1, Donya Kamravamanesh2, Marjatta Louhi-Kultanen2, Deborah Pfaff1, John Woodley1
1 Technical University of Denmark, Lyngby, Denmark
2 Aalto University, Espoo, Finland

12:30

Lunch break


Session 4b - DSP2

14:30

Integrated Magnetic Nanoparticle-Based Capture for Intensified Recombinant Protein Production in Escherichia coli
Julian Galbusera1
1 Technische Universität München, Garching bei München, Germany

14:50

Model-Based Design of Experiments for Spray Drying Using Frozen Airflow CFD-DPM Simulations
Nikolai Asbjoern Jessen1
1 Technical University of Denmark, Kgs. Lyngby, Denmark

15:10

Optimizing polyhydroxyalkanoates recovery from mixed microbial cultures using supercritical carbon dioxide coupled with solvent extraction: A Taguchi methodology approach
Mónica Carvalheira1, Filomena Freitas1, Beatriz Monteiro2, Maria. A. M. Reis1, Pedro Simões2, Lucas Filipe Tamele Junior1
1 Associate Laboratory i4HB – Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, Caparica, Portugal
2 LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, NOVA University Lisbon, Caparica, Portugal

15:30

Revisiting Expanded Bed Adsorption: Direct Protein Capture from Crude Broths Using Low-Cost Silica
Bahar Abrishamchi1, Sonja Berensmeier2, Nadja Kohn2, Florian Tuschak2
1 Technical University of Munich, Chair of Brewing and Beverage Technology, Freising, Germany
2 Technical University of Munich, Chair of Bioseparation Engineering, Garching, Germany

16:00

Poster session 2 (Foyer)

17:00

Drinks


Dinner

19:00

Dinner (New Church)


Session 2c - BCAT2

09:00

Enzymatic treatment of the lipid effluent in a continuous stirred catalytic basket reactor
Larissa Freitas1, Maria Eduarda Godoy Lopes Antonelli1, Camilla Gomes Mascarenhas1, Barbara Luisa Agra de Albuquerque1, Gabrielle Policarpo de Assis1, Vinicius Sampaio Silva1, Ariela Veloso de Paula2
1 University of São Paulo - Lorena School of Engineering, Lorena, Brazil
2 School of Pharmaceutical Sciences of the São Paulo State University (UNESP), Araraquara, Brazil

09:20

Evaluating porous materials for cultivating recombinant Synechocystis PCC6803 biofilms to produce poly-caprolactone monomers from cyclohexanol
Katja Bühler1, Alexander Franz2, Rohan Karande2, Johannes Lambrecht3, Nina Siebert2, Johanna Wiedener2
1 Helmholtz-Centre for Environmental Research, Leipzig, Germany
2 Leipzig University, Leipzig, Germany
3 Helmholtz-Centre for Environmental Research , Leipzig, Germany

09:40

Photosynthesis-driven whole-cell biocatalysis using rec. Synechocystis sp. PCC 6803 for the production of polymer-building blocks
Mahir Bozan1, Bruno Bühler2, Rohan Karande1, Nina Siebert1, Heiko Wagner1
1 Universität Leipzig, Leipzig, Germany
2 Helmholtz Centre for Environmental Research , Leipzig, Germany

10:00

Whole-cell Multi-step Biocatalysis for the Renewable Production of 6-Amino hexanoic acid
Lyn Möhrlin1, Jörg Toepel1, Adrian Tüllinghoff1, Bruno Bühler1
1 Helmholtz Centre for Environmental Research GmbH - UFZ, Leipzig, Germany

10:30

Coffee break


Session 3c - SUSD1

11:00

A Dynamic 1D Gas–Liquid Modeling Framework for Heterogeneous Bioreactors across Multiple Cultivation Modes
Julian Federico SANCHEZ CALDAS1
1 TBI (Université de Toulouse, CNRS UMR5504, INRAE UMR792, INSA), , TOULOUSE, France

11:20

A Hybrid Oxygen Capture Model Integrated with CFD for Efficient Scale-Up of a Fixed-Bed Bioreactor
Evan Claes1, Tommy Heck1, Alexandros Kiparissides2, Aikaterini Sofia Leonida2, Jan Schrooten1
1 Antleron, Leuven, Belgium
2 Aristotle University of Thessaloniki, Thessaloniki, Greece

11:40

A Low-Cost Programmable Platform for Fermentation Scale-Up Research
Wayne Aubrey 1, David Bryant1, David Jones1, Eleni Ziu1
1 Aberystwyth University, Aberystwyth, United Kingdom

12:00

A Scalable V-Shaped Photobiofilm Reactor for Limnospira platensis Biomass Production
Alexander Franz1, Rohan Karande1, Valentina Schmitz1, Johanna Wiedener1
1 Leipzig University , Leipzig, Germany

12:30

Lunch break


Session 4c - SUSD2

14:30

From oxygen transfer to transcriptional robustness: identifying the kLa modulon of Corynebacterium glutamicum
Alexander Grünberger1, Nele Grünig1, Nadja Alina Henke1, Jonas Lange1, David Nickel1, Boas Pucker2, Lars Regestein3
1 Karlsruhe Institute of Technology, Karlsruhe, Germany
2 University of Bonn, Bonn, Germany
3 Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany

14:50

High-throughput process development using modelling approaches for soluble expression in E. coli
Daniel Fleischanderl1, Jeannine Gesson1, Karin Koch1, Sophie Mischerikow1, Vignesh Rajamanickam1
1 Boehringer Ingelheim, Vienna, Austria

15:10

Model-Based Prediction of Scale-Up Behavior in Engineered E. coli for Enzyme Production: A Coupled Kinetic–CFD Strategy
Yerko Fredes1, Sushil Gaykawad2, Gerard Guerra Mas1, Antoni Casablancas Mira1, Marina Guillen Montalban1, Vetle Kjær Risinggård3, Oscar Romero1
1 Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
2 NORCE AS, Stavanger, Norway
3 NORCE AS, Kristiansand, Norway

15:30

Translating experience of gas-permeable membranes from the wastewater sector to the industrial biotechnology sector
Eoin Casey1
1 University College Dublin, Dublin 4, Ireland

16:00

Poster session 2 (Foyer)

17:00

Drinks


Dinner

19:00

Dinner (New Church)


Session 2d - USP2

09:00

Multifactorial Analysis of HEK293-F Cell Aggregation: Uncovering the Role and Interactions of Bioprocess and Medium Factors.
Anna-Lena Heins1, Niklas Nathusius1
1 Hamburg University of Technology, Hamburg, Germany

09:20

Overcoming Oxygen Transfer Limitations in High-Viscosity Aerobic Fermentation via Sparger-Integrated Internals and Engineered Bimodal Bubble Dynamics
Yingshi Chen1, Pablo Gómez1, Bernhard Huber2, Juan Mariño1, Alejandro Rosero1, Michael Zavrel1
1 Technical University of Munich. Prof. Bioprocess Engineering., Straubing, Germany
2 Technical University of Munich. Prof. Regenerative Energy Systems, Straubing, Germany

09:40

Particle-assisted cultivation of filamentous fungi in shaken bioreactors for controlling morphology
Stefan Junne1, Tolue Kheirkhah2, Julie Mathiesen1
1 Aalborg University, Esbjerg, Denmark
2 Technische Universität Berlin, Berlin, Germany

10:00

Shedding light on metabolic burden in (industrial) bioprocesses: Quantifying cellular stress across expression levels in Escherichia coli
Julia von Irmer1
1 Hamburg University of Technology, Hamburg, Germany

10:30

Coffe break


Session 3d - USP3

11:00

The Fundamentals of Bioprocessing for Integration of Tyrosine Production
Julian Kager1, Emilie Overgaard Willer1, Mykhaylo Semenov Petrov1, Deborah Pfaff1, John M. Woodley1, Lei Yang1
1 Technical University of Denmark, Kongens Lyngby, Denmark

11:20

Thirteen in One: Production and Purification of a Multi-Epitope Vaccine Candidate Against Schistosomiasis
Giovana Cappio Barazzone1, Luciana Cezar Cerqueira Leite1, Vitor dos Santos Alves1, Viviane Maimoni Gonçalves1, Ronaldo Moraes Preto1, Lázaro Moreira Marques Neto1, Kevy Pontes Eliodorio 1, Murilo Sena Amaral1, Sérgio Verjovski-Almeida1
1 Instituto Butantan, São Paulo, Brazil

11:40

Toward sustainable production of bacteriocins from lactic acid bacteria: medium optimization, fed-batch fermentation and membrane-based recovery
Alberto Alfano1
1 University of Campania L. Vanvitelli, Naples, Italy

12:00

Towards a platform process for recombinant protein production in Vibrio natriegens
Luca Heim1, Oliver Spadiut1, Ruben Stopper1
1 Technische Universitat Wien, Vienna, Austria

12:30

Lunch break


Session 4d - USP4

14:50

Upstream Process Development for Continuous pDNA manufacturing: A combined experimental and modelling approach
Dimitris Karayannis1, Alexandros Kiparissides1, Massimo Morbidelli1, Antonia Papadopoulou1, Nikolaos Stratis1
1 Aristotle University of Thessaloniki, Thessaloniki, Greece

14:30

Upstream Bioprocessing Strategies for the Co-production of Omega-3 Fatty Acids and Fucoxanthin by Phaeodactylum tricornutum
Conor Button1, John Kavanagh1, Ashley Smith1
1 University of Sydney, Sydney, Australia

15:10

Vibrio natriegens as a novel host for RNA therapeutics
Ana Azevedo1, Colin Chene1, Nuno Graça1, Lara Moeller1, Gabriel Monteiro1, Duarte Miguel Prazeres1, Ana Rita Silva-Santos1
1 IBB - Institute for Bioengineering and Biosciences, Lisbon, Portugal

15:30

pH control and ethanol-to-acetate ratio as key levers for n-caproate selectivity in pure Clostridium kluyveri batch cultures
German Aroca Arcaya1, Raul Conejeros Risco1, Fabián Otálora-Tapiero1, Pablo Salgado Jadue1, Andrés Suazo Sánchez 1
1 Ponthifical Catholic University of Valparaíso, Valparaíso, Chile

16:00

Poster session 2 (Foyer)

17:00

Drinks


Dinner

19:00

Dinner (New Church)


Session 5a - CIRCB1

09:00

Anaerobic co-fermentation of waste sludge and fruit waste: harnessing feeding dynamics for enhanced productivity and tailoring of polyhydroxyalkanoate (PHA) precursors
Joana Batista1, Mónica Carvalheira1, Nídia D. Lourenço1, Mariana Matos1, Maria A.M. Reis1
1 NOVA FCT-UCIBIO, Lisbon, Portugal

09:20

Circular Valorization of Cotton Textile waste for Poly(3-hydroxybutyrate) Production by Burkholderia thailandensis
Mariana Abreu1, Adelaide Braga2, Juliana Dias2, Filomena Freitas3, Susana Marques1, João Matias3, Patrícia Moura1, Thomas Rodrigues3, Carla Silva2, Cristiana Torres3
1 Laboratório Nacional de Energia e Geologia (LNEG), Lisbon, Portugal
2 Centro Tecnológico das Indústrias Têxtil e do Vestuário de Portugal (CITEVE), Vila Nova de Famalicão, Portugal
3 NOVA School of Science and Technology, Lisbon, Portugal

09:40

Closing the Loop: Microalgae-Derived EPS for Wastewater Treatment and Bioproduct Recovery from Malting Effluent
Asma Ahmed 1, Helena Gomes1, Konstantina Kourmentza 1, Kamonchanok Wianglor1
1 University of Nottingham, Nottingham, United Kingdom

10:00

Continuous and Mild Processing Strategies for Protein Recovery from Food Side Streams within a Circular Bioeconomy
Judith Buchmaier1, Georgios Dimopoulos2, Bettina Muster-Slawitsch1, Philipp Petermeier1, Marcus Prattes1, Hannah Wolf1
1 AEE INTEC, Gleisdorf, Austria
2 Universität für Bodenkultur Wien (BOKU), Vienna, Austria

10:30

Coffee break


Session 6a - CIRCB2

11:00

Converting waste gases into value: novel avenues for gas fermentation processes
James Heffernan1, Esteban Marcellin1, Lars Puiman1
1 University of Queensland, Brisbane, Australia

11:20

Engineered and natural phosphorus recovery through carbonaceous materials produced from contrasting lignocellulosic residues: tequila bagasse–vinasse and Eichhornia crassipes
Santiago Gutiérrez-Vargas1, Edgar Vázquez-núñez1
1 Universidad de Guanajuato, León, Mexico

11:40

Ex-ante comparison of carbon sources for large-scale aerobic fermentation
Eduardo Almeida Benalcazar1, Mickel Jansen2, Rodoula Ktori1, Henk Noorman2, Adrie Straathof1, Wouter van Winden2, Peter Verheijen1, Liang Wu2
1 Delft University of Technology, Department of Biotechnology, Delft, Netherlands
2 dsm-firmenich, Delft, Netherlands

12:00

Integrated biorefinery approach for lactic acid production and extraction: from biomass to monomer
Gennaro Agrimi1, Claudia Cappella1, Mattia Colacicco1, Isabella De Bari2, Nicola Di Fidio1, Federico Liuzzi2, Mariateresa Matera1, Isabella Pisano1
1 Università degli studi di Bari, Bari, Italy
2 Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Rotondella, Italy

12:30

Lunch break

13:30

PLENARY LECTURE TBD
Suzy Farid


Session 7a - CIRCB3

14:30

Production of Medium-Chain-Length Polyhydroxyalkanoates from Black Soldier Fly Larvae Oil by Pseudomonas chlororaphis subsp. aurantiaca
Diana Araújo1, Filomena Freitas1, Maria Reis1, Bruno Serafim1
1 NOVA School of Science and Technology, NOVA University Lisbon (NOVA FCT), Lisbon, Portugal

14:50

Sustainable Production of PHBHV with Tunable 3HV Content by Burkholderia thailandensis using Eucalyptus Bark Hydrolysate and Levulinic Acid
Diana Araújo1, Filomena Freitas1, Francisco Gírio2, Susana Marques2, João Matias1, Maria Ascensão Reis1, Thomas Rodrigues1, Francisco Santos1
1 NOVA School of Science and Technology, Lisbon, Portugal
2 Laboratório Nacional de Energia e Geologia (LNEG), Lisbon, Portugal

15:10

Sustainable production of the plant probiotic K. pseudosacchari TL13 and of its exopolysaccharide with potential biotechnological applications
Donatella Cimini1, Sergio D'Ambrosio1
1 University of Campania L. Vanvitelli, Caserta, Italy

15:30

Techno-Economic and Life Cycle Assessment of Industrial-Scale High-Pressure Extraction of High-Value Bioactives from Forest-Derived Biomass Side Streams
Rofice Dickson1, Uswaththa Liyanage Marian Sureshi Manthila Perera1
1 Aalto University, Espoo, Finland

16:00

CLOSING


Session 5c - PAT1

09:00

Applications of Raman Spectroscopy and Mid-Infrared Analytics for Characterization of T-Cell Phenotype and Metabolic State
William Kelly1, Stephen Spada2
1 Villanova, Villanova, PA, United States of America
2 Johnson & Johnson, Malvern, PA, United States of America

09:20

Automated PAT Model Development Using Genetic Algorithm-Based Pipeline Optimization
Julian Gentes1, Jürgen Hubbuch1
1 Karlsruher Institute of Technology, Karlsruhe, Germany

09:40

Balancing Prediction Performance and Spectral Interpretability: Multi-Metric Guided Design of Preprocessing Pipelines for Rapid Calibration of Raman Spectroscopy Models.
Marieke Klijn1, Gianmarco Luchetti Sfondalmondo1
1 Delft University of Technology , Delft, Netherlands

10:00

Multimodal spectroscopy-based real-time monitoring and anomaly detection in ADC manufacturing process
Subhankar Metya1, Anurag Rathore1
1 Indian Institute of Technology Delhi, New Delhi, India

10:30

Coffee break


Session 6c - PAT2

11:00

Predictive control and real-time optimization is a necessity for robust and high performing bioprocesses: experimental emphasis from P. chrysogenum, CHO, C. glutamicum and E. coli
Julian Kager1, Philipp Pably1
1 Technical University of Denmark, Kongens Lyngby, Denmark

11:20

Scalable, continuous production of mRNA with real-time prediction of titer and purity via a Digital Twin
Simon Baukmann1, Alina Hengelbrock1, Axel Schmidt1, Jochen Strube2
1 Institute for Separation and Process Technology, Clausthal University of Technology, Clausthal-Zellerfeld, Germany
2 Institute for Separation and Process Technology, Clausthal University of Technology, Göttingen

11:40

Subpopulation-based bioprocess design and control
Frank Delvigne1
1 University of Liège, Gembloux, Belgium

12:00

Establishment and Digital Monitoring of Quillaja saponaria Plant Cell Suspension Cultures for QS-21 Production
Simon Baukmann1, Elias Belz2, Robert Hänsch2, Jutta Schulze2, Jochen Strube1
1 Institute for Separation and Process Technology, Clausthal University of Technology, Clausthal-Zellerfeld, Germany
2 Institut for Plant Biology, Braunschweig University of Technology, Braunschweig, Germany

12:30

Lunch break


Session 7c - EDU

14:30

Avatar-based Conversational AI Assistant in Chemical Engineering Education
Fiammetta Caccavale1, Ulrich Krühne1
1 Technical University of Denmark, Kgs. Lyngby, Denmark

14:50

Closing the Gap: Challenge-Based, Industry co-created laboratory for undergraduate bioprocess development
Brian Freeland1
1 Dublin City University, Dublin, Ireland

15:10

Helix Lab - Center for Applied Research and Education in an Industrial Environment
Anette Birck1, Kresten Kromphardt1
1 Helix Lab, Kalundborg, Denmark

15:30

More than just modelling and programming: educating engineers to leverage their digital skills in practice.
Cees Haringa1
1 Tu Delft, Delft, Netherlands


Session 5d - BPHARM1

09:00

A phenomenological modeling approach to designing freezing processes for human induced pluripotent stem cell-derived spheroids
Yurina Aoyama1, Masaharu Fujioka2, Yusuke Hayashi2, Hirokazu Sugiyama2, Yuta Yamaguchi1
1 Sumitomo Pharma Co., Ltd., Osaka, Japan
2 The University of Tokyo, Tokyo, Japan

09:20

Cell-Tolerant Radial Affinity Chromatography for Capture of Monoclonal Antibodies from Unclarified Harvest
Michel Eppink1, Marcel Ottens2, Ivo Tjalma2
1 Byondis B.V. / Delft University of Technology, Nijmegen / Delft, Netherlands
2 Delft University of Technology, Delft, Netherlands

09:40

CFD-DEM characterization of a 250 mL stirred-tank bioreactor for shear-sensitive stem-cell microcarrier cultures
Stijn de Smit1, Cees Haringa1, Brenda Juarez Garza1, Marcel Ottens1, Ryan Rautenbach2, Michael Schlüter2, Ramon Van Valderen1
1 Delft University of Technology (TU Delft), Delft, Netherlands
2 Hamburg University of Technology, Hamburg, Germany

10:00

Engineering Simplified and Scalable Manufacturing Platforms for Circular RNA Therapeutics
Shams Hussein1
1 UCL, LONDON, United Kingdom

10:30

Coffee break


Session 6d - BFHARM2

11:00

PEGYLATION OF SILK FIBROIN NANOPARTICLES FOR DELIVERY OF 3,3’-DIINDOLYLMETHANE IN A ROUTE FOR OBESITY MANAGEMENT
Jorge Benavides1, Aleyda M. Escobar-Fernández1, Helen Y. Lorenzo-Anota2, Omar Lozano2, Karla Mayolo-Deloisa1, Adriana Morales-Martínez2, Marcel Ottens3, Marco Rito-Palomares2, Calef Sánchez-Trasviña1, Diana Angélica Tapia-Sidas1
1 Tecnologico de Monterrey, Institute for Obesity Research, Escuela de Ingeniería y Ciencias, Monterrey, Nuevo León, Mexico
2 Tecnologico de Monterrey, Institute for Obesity Research, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo León, Mexico
3 Department of Biotechnology, Delft University of Technology, Delft, Netherlands

11:20

PROCESS DEVELOPMENT FOR SCALABLE PRODUCTION OF IPSC-DERIVED HEMATOPOIETIC STEM/PROGENITOR CELLS IN STIRRED-TANK BIOREACTORS
Brenda Juarez Garza1, Marieke Klijn1, Emile van den Akker2, Ramon van Valderen1, Eszter Varga2
1 Delft University of Technology, Delft, Netherlands
2 Sanquin Research Amsterdam, Amsterdam, Netherlands

11:40

Deep hybrid modelling of CHO platforms: addressing multiple development campaigns across different antibody products
Leonor Gündersen1, Rui Oliveira1, José Pinto1
1 Systems Biology & Engineering group, Chemistry Department, School of Sciences and Technology, NOVA School of Science and Technology, Associação para a Inovação e Desenvolvimento da FCT NOVA, Campus de Caparica, Lisbon, Portugal

12:30

Lunch break


Session 5b - DSP3

09:00

Rotating Dynamic Crossflow Microfiltration as an Active Harvesting Platform for Continuous High-Cell-Density Escherichia coli Biomanufacturing
Sonja Berensmeier1, Julian Galbusera1, Paul Jacoby1
1 Technical University of Munich, Chair of Bioseparation Engineering, Garching, Germany

09:20

Steric exclusion chromatography for scalable purification of ssDNA scaffolds in DNA-origami biomanufacturing
Ana Azevedo1, Reine Bourdin1, Duarte Miguel Prazeres1, Sebastião Santos Pereira1, Ana Rita Silva-Santos1
1 iBB – Institute for Bioengineering and Biosciences, Lisboa, Portugal

09:40

Digital Twin aided Process Development and Enablement of Autonomous Manufacturing of Synthetic Peptides
Marcel Broocks1, Jessica Lütge1, Andreas Potschka2, Axel Schmidt1, Jochen Strube1, Alexander Uhl1
1 Institut for Separation and Process Technology, TU Clausthal, Clausthal-Zellerfeld, Germany
2 Institute of Mathematics, TU Clausthal, Clausthal-Zellerfeld, Germany

10:00

A Mechanistic Model for Predicting AAV9 Recovery During Ion-Exchange Purification
Saleheen Khan1, Alexandros Kiparissides2, Gabriele Mura3
1 Trellis Research Group, Department of Cellular and Molecular Medicine, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
2 Trellis Research Group, Department of Cellular and Molecular Medicine, Department of Microbiology, Immunology and Transplantation, KU Leuven, Thessaloniki, Greece
3 Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece

10:30

Coffee break


Session 6b - BF&CA1

11:00

Dairy Side-Stream Valorization Through Microbial Lipid Production: Comparative Assessment of Yarrowia lipolytica and Candida kefyr

11:20

Real-time monitoring of stress responses of lactic acid bacteria for industrial applications
Alexander Angersbach1, Anne Kathrine Clausen2, Stefan Junne2, Marie Louise Hammershøj Rose2
1 biotronix GmbH, Hennigsdorf, Germany
2 Aalborg University, Esbjerg, Denmark

11:40

Yarrowia-driven solid-state fermentation of Portuguese fruit surpluses
Liliana P. Araújo1, Isabel Belo1, Ana Rita Costa1, Marlene Lopes1
1 Centre of Biological Engineering - University of Minho, Braga, Portugal

12:00

Life cycle assessment of integral production chains for cellular agriculture products
Joana Carvalho Pereira1
1 Delft University of Technology, Delft, Netherlands

12:30

Lunch break


Session 7b - BF&CA2

14:30

A Platform Approach to Cultivated Meat: scalable cells, high-throughput screening, and computational modeling
Cees Haringa1, Marcel Ottens1, Ben Tumulero1
1 Delft University of Technology, Delft, Netherlands

14:50

Cultured seafood: a tissue engineering approach
Paola Alberte1, Marta Esteves1, Frederico Ferreira1, Afonso Gusmão 2, Diana Marques3
1 DBE, iBB, Instituto Superior Técnico, Universidade de Lisboa and i4HB-Institute for Health and Bioeconomy, Lisboa, Portugal
2 DBE, DMEc, iBB, IDMEC, Instituto Superior Técnico, Universidade de Lisboa and i4HB-Institute for Health and Bioeconomy, Lisboa, Portugal
3 DBE, iBB, Instituto Superior Técnico, Universidade de Lisboa and i4HB-Institute for Health and Bioeconomy, Lisboa, Portugal

15:10

How large can you go? Model-based screening of bioreactors for large scale cultivated meat production.
Pieter Brorens1, Cees Haringa1, Lies Levering1, Marcel Ottens1
1 Delft University of Technology, Delft, Netherlands

15:30

Integrating upstream cultivations and downstream processes: The impact of cultivation conditions on intracellular protein release from mildly disrupted Saccharomyces cerevisiae
Rammelaere, Tim